Thursday, March 13, 2014
The Light House's Autism Education Conference - March 31st Groton, CT
On
March 31st, Dr. O'Hara will be speaking at The Light House's Autism
Education Conference at the Mystic Marriott in Groton, CT.
The link below is a recent Article about the Light House.
http://ihealthnow.org/
The link below is a recent Article about the Light House.
http://ihealthnow.org/
Babies born via C-section show higher obesity risk
From DoctorsLounge.com/HealthDay News (2/26):
Babies born via C-section show higher obesity risk
Babies born via cesarean section were 26% more likely to be overweight or obese later in life compared with babies delivered vaginally, according to a study in the journal PLOS ONE. Researchers said the reason behind the apparent association remains unclear and may be due to other factors.
http://www.doctorslounge.com/
Babies born via C-section show higher obesity risk
Babies born via cesarean section were 26% more likely to be overweight or obese later in life compared with babies delivered vaginally, according to a study in the journal PLOS ONE. Researchers said the reason behind the apparent association remains unclear and may be due to other factors.
http://www.doctorslounge.com/
PANDAS in the news...
PANDAS in the news...
Dr. O'Hara is on the CT PANDAS Task Force referenced in the video below, making recommendations and raising awareness.
http://www.nbcconnecticut.com/on-air/as-seen-on/248442521.html
Dr. O'Hara is on the CT PANDAS Task Force referenced in the video below, making recommendations and raising awareness.
http://www.nbcconnecticut.com/on-air/as-seen-on/248442521.html
Vitamin D hormone regulates serotonin synthesis
From Nutrition and Metabolism Center,
Children's Hospital Oakland Research Institute, Oakland, California, USA
by authors Rhonda P. Patrick and Bruce N. Ames
Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism
Abstract
Serotonin and vitamin D have been proposed to play a role in autism; however, no causal mechanism has been established. Here, we present evidence that vitamin D hormone (calcitriol) activates the transcription of the serotonin-synthesizing gene tryptophan hydroxylase 2 (TPH2) in the brain at a vitamin D response element (VDRE) and represses the transcription of TPH1 in tissues outside the blood-brain barrier at a distinct VDRE. The proposed mechanism explains 4 major characteristics associated with autism: the low concentrations of serotonin in the brain and its elevated concentrations in tissues outside the blood-brain barrier; the low concentrations of the vitamin D hormone precursor 25-hydroxyvitamin D [25(OH)D3]; the high male prevalence of autism; and the presence of maternal antibodies against fetal brain tissue. Two peptide hormones, oxytocin and vasopressin, are also associated with autism and genes encoding the oxytocin-neurophysin I preproprotein, the oxytocin receptor, and the arginine vasopressin receptor contain VDREs for activation. Supplementation with vitamin D and tryptophan is a practical and affordable solution to help prevent autism and possibly ameliorate some symptoms of the disorder.—Patrick, R. P., Ames, B. N. Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism
http://www.fasebj.org/content/early/2014/02/14/fj.13-246546.abstract
Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism
Abstract
Serotonin and vitamin D have been proposed to play a role in autism; however, no causal mechanism has been established. Here, we present evidence that vitamin D hormone (calcitriol) activates the transcription of the serotonin-synthesizing gene tryptophan hydroxylase 2 (TPH2) in the brain at a vitamin D response element (VDRE) and represses the transcription of TPH1 in tissues outside the blood-brain barrier at a distinct VDRE. The proposed mechanism explains 4 major characteristics associated with autism: the low concentrations of serotonin in the brain and its elevated concentrations in tissues outside the blood-brain barrier; the low concentrations of the vitamin D hormone precursor 25-hydroxyvitamin D [25(OH)D3]; the high male prevalence of autism; and the presence of maternal antibodies against fetal brain tissue. Two peptide hormones, oxytocin and vasopressin, are also associated with autism and genes encoding the oxytocin-neurophysin I preproprotein, the oxytocin receptor, and the arginine vasopressin receptor contain VDREs for activation. Supplementation with vitamin D and tryptophan is a practical and affordable solution to help prevent autism and possibly ameliorate some symptoms of the disorder.—Patrick, R. P., Ames, B. N. Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism
http://www.fasebj.org/content/early/2014/02/14/fj.13-246546.abstract
Royal Caribbean is first 'autism-friendly' cruise line
From USA Today (2/20):
Royal Caribbean is first 'autism-friendly' cruise line
http://www.usatoday.com/story/cruiselog/2014/02/20/autistic-child-autism-friendly-cruise/5640629/
Royal Caribbean is first 'autism-friendly' cruise line
http://www.usatoday.com/story/cruiselog/2014/02/20/autistic-child-autism-friendly-cruise/5640629/
Probiotics may protect infants from developing colic
From The Wall Street Journal (tiered subscription model) (1/13):
Probiotics may protect infants from developing colic
Newborns who were given a daily dose of the probiotic Lactobacillus reuteri during the first three months of life had reduced time of inconsolable crying compared with the placebo group, an Italian study showed. Early introduction to probiotics was also associated with a lower incidence of gastrointestinal problems, including constipation and regurgitation, researchers reported in the journal JAMA Pediatrics.
http://online.wsj.com/news/articles/SB10001424052702303819704579318703183361902?mod=dist_smartbrief
Probiotics may protect infants from developing colic
Newborns who were given a daily dose of the probiotic Lactobacillus reuteri during the first three months of life had reduced time of inconsolable crying compared with the placebo group, an Italian study showed. Early introduction to probiotics was also associated with a lower incidence of gastrointestinal problems, including constipation and regurgitation, researchers reported in the journal JAMA Pediatrics.
http://online.wsj.com/news/articles/SB10001424052702303819704579318703183361902?mod=dist_smartbrief
FDA OKs Postnatal Blood Test for Intellectual Disabilities
From Medscape (1/17/14):
FDA OKs Postnatal Blood Test for Intellectual Disabilities
The US Food and Drug Administration (FDA) has cleared for marketing the CytoScan Dx Assay (Affymetrix), which detects chromosomal variations that may underlie a child's developmental delay or intellectual disability.
http://www.medscape.com/viewarticle/819387
FDA OKs Postnatal Blood Test for Intellectual Disabilities
The US Food and Drug Administration (FDA) has cleared for marketing the CytoScan Dx Assay (Affymetrix), which detects chromosomal variations that may underlie a child's developmental delay or intellectual disability.
http://www.medscape.com/viewarticle/819387
Mycoplasma Fermentans and deciliation as a precursor to Regressive Autism
Mycoplasma Fermentans and deciliation as a precursor to Regressive Autism by Bill Welsh
The worldwide increase in the diagnosis of autism and autistic spectrum disorder (ASD) together with increasing reports of a regressive onset has caused many to argue that the condition should no longer be viewed as solely, or even mainly, genetic in origin, environmental factors must be implicated, particularly those of bacterial or viral genesis.
Pathogenic substances entering the bloodstream of developing children merit consideration and investigation in the search for causation.
The witness and evidence of parents may provide persuasive clues...
Full article:
http://homepage.ntlworld.com/
The worldwide increase in the diagnosis of autism and autistic spectrum disorder (ASD) together with increasing reports of a regressive onset has caused many to argue that the condition should no longer be viewed as solely, or even mainly, genetic in origin, environmental factors must be implicated, particularly those of bacterial or viral genesis.
Pathogenic substances entering the bloodstream of developing children merit consideration and investigation in the search for causation.
The witness and evidence of parents may provide persuasive clues...
Full article:
http://homepage.ntlworld.com/
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